Recent past, peptide research gained unprecedented growth for a broad range of applications in medicine, biotechnology, chemical biology, and therapeutic research. Peptide therapeutics have been a highly specific and selective mechanism of action closely mimic natural biochemical pathways that translate into excellent safety and efficacy profile. In light of attractive pharmacological profile and commercial impact, industry and academia have been showing renewed interest in peptide therapies.
The prospects for peptide research and development is very encouraging. The marketing approvals for peptide drugs increasing year by year, over 60 peptide drugs approved by North America, Europe, and the Asia Pacific markets, and more than 150 peptides in active clinical trials. The increased demand for peptide therapeutics, the global market is estimated to reach the US $24 billion in 2020.
Peptides are being highly potent signal transduction molecules have been currently evaluating towards therapeutic areas of metabolic diseases, oncology, infectious diseases, and inflammation. However, peptide drug discovery was hampered due to short plasma half-life and limited oral bioavailability of native peptides. Traditional peptide drug design has focused on techniques that minimize these challenges. Bioavailability of peptides can be improved by primary structure modifications and half-life extension can be achieved by secondary structure modifications. Natural or synthetic peptide serve diverse applications in biopharmaceutical drug discovery, epitope mapping, and vaccine development.
In general, peptides can be prepared chemically by either liquid-phase peptide synthesis (LPPS) or by solid-phase peptide synthesis (SPPS). LPPS is an elegant technique for the large-scale synthesis of short peptides whereas SPPS is highly significant for the manufacturing of longer peptides or small proteins. Prayog life science has expertise in both, liquid-phase and solid-phase peptide synthesis, which allows us to deliver numerous peptides for therapeutic and diagnostic applications. Our new redox peptide ligation technology offers more flexibility to get access to the longer peptides with high-efficiency and accuracy that also enables shorter delivery times. We offer a wide range of peptide synthesis services for API peptides and library of custom peptides with the purity ranging from research grade to commercial grade.
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