Recent past, peptide research gained unprecedented growth for a broad range of applications in medicine, biotechnology, chemical biology, and therapeutic research. Peptide therapeutics have been a highly specific and selective mechanism of action that closely mimic natural biochemical pathways that translate into excellent safety and efficacy profile. In light of its attractive pharmacological profile and commercial impact, industry and academia have been showing renewed interest in peptide therapies.
The prospects for peptide research and development is very encouraging. The marketing approvals for peptide drugs increasing year by year, over 60 peptide drugs approved by North America, Europe, and the Asia Pacific markets, and more than 150 peptides in active clinical trials. The increased demand for peptide therapeutics, the global market is estimated to reach the US $24 billion in 2020.
Peptides are highly potent signal transduction molecules and are currently evaluating towards therapeutic areas of metabolic diseases, oncology, infectious diseases, and inflammation. However, peptide drug discovery was hampered due to short plasma half-life and limited oral bioavailability of native peptides. Traditional peptide drug design has focused on techniques that minimize these challenges. Bioavailability of peptides can be improved by primary structure modifications and half-life extension can be achieved by secondary structure modifications. Natural or synthetic peptide serve diverse applications in biopharmaceutical drug discovery, epitope mapping, and vaccine development.
Our Custom Peptide Services
Prayog life science has expertise in both, liquid-phase (LPPS) and solid-phase peptide synthesis (SPPS), which allows us to deliver numerous peptides for therapeutic and diagnostic applications. Our new redox peptide ligation technology offers more flexibility to get access to the longer peptides with high-efficiency and accuracy that also enables shorter delivery times.
We specialize in the synthesis of high-quality peptides at a competitive price. We offer a wide range of peptide synthesis services for API peptides, cosmetic peptides, and library of custom peptides with the purity ranging from research grade to commercial grade. Our manufacturing site in India have capability of peptide synthesis at various scales from milligrams to kilograms. Also, we are producing a variety of coupling reagents that offering us to deliver the custom peptides at affordable price.
Tagging peptides with fluorescent dyes delivers powerful tools for exploring biological relevant interactions like receptor-ligand-binding, protein structures, and enzyme activity. Fluorophores can be combined to the N-terminus of a resin-bound peptide before other protecting groups are removed and the labelled peptide is released from the resin. Reactive BODIPY FL, fluorescein, and Cyanine 3 dyes are stable enough to resist the harsh deprotection conditions.
BODIPY FL dye is a bright, green-fluorescent dye with similar excitation and emission to fluorescein (FITC). It has a high extinction coefficient and fluorescence quantum yield and is relatively insensitive to solvent polarity and pH change. In contrast to the highly water-soluble fluorophores Cyanine 3 (CY3) and fluorescein (FITC), BODIPY dyes have unique hydrophobic properties ideal for staining lipids, membranes, and other lipophilic compounds.
We offer BODIPY FL dye conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates optimized for cellular labelling and detection. In addition, reactive dye forms and protein labelling kits are available to allow you to generate your own protein conjugates or probes.